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Osteoporosis drug Actonel used by millions of Americans has been linked to Osteonecrosis of the Jaw (ONJ) or "dead jaw.". There are several other bisphosphonate drugs on the market, all of which have been linked to ONJ (1). Actonel is an oral bisphoshonate drug similar to. 15 Aug 2005. Actonel with Calcium is a product that provides the fracture. Most ONJ cases have occurred in cancer patients undergoing
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